Edward Hughes Glidden, a descendant of Capt. John Locke, rebelled against following the family business in Cleveland and chose to study architecture instead. He went to Baltimore and became a prominent architect, known for designing large, high-end apartment buildings. But his final and finest project was the design of the Sydenham Hospital for Communicable Diseases, a collection of several buildings in the Italian Renaissance Revival style set on a sprawling 33-acre campus. It was completed in 1924 and operated until 1949.